Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and p...

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Main Authors:	Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner, Mario A. Acuña, Hendrik Wildner, Gonzalo E. Yévenes, Andrea Dieter, Hiroshi Kawasaki, Michael O. Hottiger, Hanns Ulrich Zeilhofer, Jean-Marc Fritschy, Shiva K. Tyagarajan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-11-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13365

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spelling	doaj-73ddc1c5e39d47848b61414b2085adaa2021-05-11T10:55:30ZengNature Publishing GroupNature Communications2041-17232016-11-017111610.1038/ncomms13365Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmissionHimanish Ghosh0Luca Auguadri1Sereina Battaglia2Zahra Simone Thirouin3Khaled Zemoura4Simon Messner5Mario A. Acuña6Hendrik Wildner7Gonzalo E. Yévenes8Andrea Dieter9Hiroshi Kawasaki10Michael O. Hottiger11Hanns Ulrich Zeilhofer12Jean-Marc Fritschy13Shiva K. Tyagarajan14Institute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichDepartment of Molecular Mechanisms of Disease, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichDepartment of Molecular and Systems Neurobiology, Graduate School of Medicine, The University of TokyoDepartment of Molecular Mechanisms of Disease, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichInstitute of Pharmacology and Toxicology, University of ZurichGephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation.https://doi.org/10.1038/ncomms13365
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Himanish Ghosh Luca Auguadri Sereina Battaglia Zahra Simone Thirouin Khaled Zemoura Simon Messner Mario A. Acuña Hendrik Wildner Gonzalo E. Yévenes Andrea Dieter Hiroshi Kawasaki Michael O. Hottiger Hanns Ulrich Zeilhofer Jean-Marc Fritschy Shiva K. Tyagarajan
spellingShingle	Himanish Ghosh Luca Auguadri Sereina Battaglia Zahra Simone Thirouin Khaled Zemoura Simon Messner Mario A. Acuña Hendrik Wildner Gonzalo E. Yévenes Andrea Dieter Hiroshi Kawasaki Michael O. Hottiger Hanns Ulrich Zeilhofer Jean-Marc Fritschy Shiva K. Tyagarajan Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission Nature Communications
author_facet	Himanish Ghosh Luca Auguadri Sereina Battaglia Zahra Simone Thirouin Khaled Zemoura Simon Messner Mario A. Acuña Hendrik Wildner Gonzalo E. Yévenes Andrea Dieter Hiroshi Kawasaki Michael O. Hottiger Hanns Ulrich Zeilhofer Jean-Marc Fritschy Shiva K. Tyagarajan
author_sort	Himanish Ghosh
title	Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
title_short	Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
title_full	Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
title_fullStr	Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
title_full_unstemmed	Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission
title_sort	several posttranslational modifications act in concert to regulate gephyrin scaffolding and gabaergic transmission
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-11-01
description	Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transmission that involve acetylation, SUMOylation and phosphorylation.
url	https://doi.org/10.1038/ncomms13365
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Several posttranslational modifications act in concert to regulate gephyrin scaffolding and GABAergic transmission

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