α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties

α-Tocopherol loaded thermosensitive polymer nanoparticles: preparation, in vitro release and antioxidant properties

Abstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparati...

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Bibliographic Details
Main Authors: Cirley Quintero, Ricardo Vera, Leon Dario Perez
Format: Article
Language:English
Published: Associação Brasileira de Polímeros
Series:Polímeros
Subjects:
α-tocopherol
polycaprolactone
thermosensitive nanoparticles
triblock copolymer
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282016000400304&lng=en&tlng=en
Description
Summary:Abstract α-Tocopherol is the most bioavailable and active compound found in vitamin E with potential application in pharmaceutical, alimentary and cosmetic industries. However, its low solubility in aqueous medium and environmental instability limit its dosage. In this paper, we report the preparation of α-tocopherol loaded nanoparticles (TOC-NP) based on amphiphilic thermosensitive triblock copolymers PNIPAM-b-PCL-b-PNIPAM. The nanoparticles exhibited a core – shell structure, were positively charged and presented average diameters below 300 nm. TOC-NP presented controlled release of α-tocopherol at room temperature along 140h, and exhibited antioxidant properties in aqueous medium.
ISSN:1678-5169

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