Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.

Bibliographic Details
Main Authors:	Mykhaylo Demydchuk, Chris H. Hill, Aiwu Zhou, Gábor Bunkóczi, Penelope E. Stein, Denis Marchesan, Janet E. Deane, Randy J. Read
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15786

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spelling	doaj-73c38b90598b4907b8cedce5ff4f26cb2021-05-11T07:11:09ZengNature Publishing GroupNature Communications2041-17232017-06-01811910.1038/ncomms15786Insights into Hunter syndrome from the structure of iduronate-2-sulfataseMykhaylo Demydchuk0Chris H. Hill1Aiwu Zhou2Gábor Bunkóczi3Penelope E. Stein4Denis Marchesan5Janet E. Deane6Randy J. Read7Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical CampusCambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical CampusKey Laboratory of Cell Differentiation and Apoptosis of Ministry of Education of China, Shanghai Jiaotong University School of MedicineCambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical CampusDepartment of Medicine, University of Cambridge, Cambridge Biomedical CampusDepartment of Medicine, University of Cambridge, Cambridge Biomedical CampusCambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical CampusCambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge Biomedical CampusHunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.https://doi.org/10.1038/ncomms15786
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read
spellingShingle	Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read Insights into Hunter syndrome from the structure of iduronate-2-sulfatase Nature Communications
author_facet	Mykhaylo Demydchuk Chris H. Hill Aiwu Zhou Gábor Bunkóczi Penelope E. Stein Denis Marchesan Janet E. Deane Randy J. Read
author_sort	Mykhaylo Demydchuk
title	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_short	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_full	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_fullStr	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_full_unstemmed	Insights into Hunter syndrome from the structure of iduronate-2-sulfatase
title_sort	insights into hunter syndrome from the structure of iduronate-2-sulfatase
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Hunter syndrome is a lysosomal storage disease caused by mutations in the enzyme iduronate-2-sulfatase (IDS). Here, the authors present the IDS crystal structure and give mechanistic insights into mutations that cause Hunter syndrome.
url	https://doi.org/10.1038/ncomms15786
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Insights into Hunter syndrome from the structure of iduronate-2-sulfatase

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