Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies

Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies

Background: There is an urgent need to develop and implement low cost, high-throughput standardized methods for routine molecular assessment of transplant biopsies. Given the vast archive of formalin-fixed and paraffin-embedded (FFPE) tissue blocks in transplant centers, a reliable protocol for util...

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Bibliographic Details
Main Authors: Tara Sigdel, Mark Nguyen, Juliane Liberto, Dejan Dobi, Henrik Junger, Flavio Vincenti, Zoltan Laszik, Minnie M. Sarwal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Medicine
Subjects:
kidney transplantation
acute rejection
biomarker
transcriptomics analysis
FFPE
Online Access:https://www.frontiersin.org/article/10.3389/fmed.2019.00213/full

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