Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model

Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model

Abstract Background Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with...

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Bibliographic Details
Main Authors: Huihui Zeng, Tiao Li, Xue He, Shan Cai, Hong Luo, Ping Chen, Yan Chen
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Respiratory Research
Subjects:
Oxidative stress
Apoptosis
Hypermethylation
Bcl-2
DNMT1
Online Access:http://link.springer.com/article/10.1186/s12931-020-01495-w

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