Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection

Membranous glomerulopathy is a well-recognized extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The authors report two cases of HBV-related nephrotic syndrome treated with lamivudine. A 46-year-old Chinese man had a hepatitis B e antigen seroconversion along with improvement...

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Main Authors: SI Gan, SM Devlin, NW Scott-Douglas, KW Burak
Format: Article
Language:English
Published: Hindawi Limited 2005-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2005/378587
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spelling doaj-73b376c46be2433e953d355b1556d33c2020-11-24T23:04:53ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002005-01-01191062562910.1155/2005/378587Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B InfectionSI Gan0SM Devlin1NW Scott-Douglas2KW Burak3Divisions of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDivisions of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDivisions of Nephrology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDivisions of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, CanadaMembranous glomerulopathy is a well-recognized extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The authors report two cases of HBV-related nephrotic syndrome treated with lamivudine. A 46-year-old Chinese man had a hepatitis B e antigen seroconversion along with improvement in his nephrotic syndrome after lamivudine therapy. Two years after treatment was discontinued, a reactivation of HBV was successfully treated again with lamivudine. A 44-year-old Chinese woman, who was intolerant of interferon, was treated with lamivudine for 15 months without a virological response. However, two years after completing lamivudine, her nephrotic syndrome resolved. Implications for the treatment of HBV-related glomerulopathy and a review of the literature are presented.http://dx.doi.org/10.1155/2005/378587
collection DOAJ
language English
format Article
sources DOAJ
author SI Gan
SM Devlin
NW Scott-Douglas
KW Burak
spellingShingle SI Gan
SM Devlin
NW Scott-Douglas
KW Burak
Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
Canadian Journal of Gastroenterology
author_facet SI Gan
SM Devlin
NW Scott-Douglas
KW Burak
author_sort SI Gan
title Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
title_short Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
title_full Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
title_fullStr Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
title_full_unstemmed Lamivudine for the Treatment of Membranous Glomerulopathy Secondary to Chronic Hepatitis B Infection
title_sort lamivudine for the treatment of membranous glomerulopathy secondary to chronic hepatitis b infection
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2005-01-01
description Membranous glomerulopathy is a well-recognized extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The authors report two cases of HBV-related nephrotic syndrome treated with lamivudine. A 46-year-old Chinese man had a hepatitis B e antigen seroconversion along with improvement in his nephrotic syndrome after lamivudine therapy. Two years after treatment was discontinued, a reactivation of HBV was successfully treated again with lamivudine. A 44-year-old Chinese woman, who was intolerant of interferon, was treated with lamivudine for 15 months without a virological response. However, two years after completing lamivudine, her nephrotic syndrome resolved. Implications for the treatment of HBV-related glomerulopathy and a review of the literature are presented.
url http://dx.doi.org/10.1155/2005/378587
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AT smdevlin lamivudineforthetreatmentofmembranousglomerulopathysecondarytochronichepatitisbinfection
AT nwscottdouglas lamivudineforthetreatmentofmembranousglomerulopathysecondarytochronichepatitisbinfection
AT kwburak lamivudineforthetreatmentofmembranousglomerulopathysecondarytochronichepatitisbinfection
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