Mechanical sensitivity of Piezo1 ion channels can be tuned by cellular membrane tension

Piezo1 ion channels mediate the conversion of mechanical forces into electrical signals and are critical for responsiveness to touch in metazoans. The apparent mechanical sensitivity of Piezo1 varies substantially across cellular environments, stimulating methods and protocols, raising the fundament...

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Bibliographic Details
Main Authors: Amanda H Lewis, Jörg Grandl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/12088