Local intramuscular administration of ANG1 and VEGF genes using plasmid vectors mobilizes CD34+ cells to peripheral tissues and promotes angiogenesis in an animal model

Local intramuscular administration of ANG1 and VEGF genes using plasmid vectors mobilizes CD34+ cells to peripheral tissues and promotes angiogenesis in an animal model

Introduction: Patients with peripheral artery disease have poor prognosis despite advances in vascular surgery. Therefore, attempts have been made at using gene and cell therapy to stimulate angiogenesis in the lower limbs in patients with critical lower limb ischemia (CLI). Methods: The study inclu...

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Bibliographic Details
Main Authors: Jan Paweł Skóra, Maciej Antkiewicz, Diana Kupczyńska, Katarzyna Kulikowska, Bartłomiej Strzelec, Dariusz Janczak, Piotr Barć
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Gene therapy
ANG1
VEGF
CD34+
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221009707

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