Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism

Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In rece...

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Main Authors: Jin He, Peiwen Zhang, Linyuan Shen, Lili Niu, Ya Tan, Lei Chen, Ye Zhao, Lin Bai, Xiaoxia Hao, Xuewei Li, Shunhua Zhang, Li Zhu
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
short-chain fatty acids
inflammation
glycose and lipid metabolism
signalling pathways
Online Access:https://www.mdpi.com/1422-0067/21/17/6356
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spelling doaj-73a3740293374637a1d0956208c63bff2020-11-25T03:40:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-09-01216356635610.3390/ijms21176356Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid MetabolismJin He0Peiwen Zhang1Linyuan Shen2Lili Niu3Ya Tan4Lei Chen5Ye Zhao6Lin Bai7Xiaoxia Hao8Xuewei Li9Shunhua Zhang10Li Zhu11College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaCollege of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, ChinaShort-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.https://www.mdpi.com/1422-0067/21/17/6356short-chain fatty acidsinflammationglycose and lipid metabolismsignalling pathways
collection DOAJ
language English
format Article
sources DOAJ
author Jin He
Peiwen Zhang
Linyuan Shen
Lili Niu
Ya Tan
Lei Chen
Ye Zhao
Lin Bai
Xiaoxia Hao
Xuewei Li
Shunhua Zhang
Li Zhu
spellingShingle Jin He
Peiwen Zhang
Linyuan Shen
Lili Niu
Ya Tan
Lei Chen
Ye Zhao
Lin Bai
Xiaoxia Hao
Xuewei Li
Shunhua Zhang
Li Zhu
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
International Journal of Molecular Sciences
short-chain fatty acids
inflammation
glycose and lipid metabolism
signalling pathways
author_facet Jin He
Peiwen Zhang
Linyuan Shen
Lili Niu
Ya Tan
Lei Chen
Ye Zhao
Lin Bai
Xiaoxia Hao
Xuewei Li
Shunhua Zhang
Li Zhu
author_sort Jin He
title Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
title_short Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
title_full Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
title_fullStr Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
title_full_unstemmed Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism
title_sort short-chain fatty acids and their association with signalling pathways in inflammation, glucose and lipid metabolism
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2020-09-01
description Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.
topic short-chain fatty acids
inflammation
glycose and lipid metabolism
signalling pathways
url https://www.mdpi.com/1422-0067/21/17/6356
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