Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis
IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 re...
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01573/full |
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doaj-73a21a0804db43e2ae755a1ccfc4ed2f2020-11-25T02:58:24ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01573541526Interleukin-27 Functional Duality Balances Leishmania Infectivity and PathogenesisAbdollah Jafarzadeh0Abdollah Jafarzadeh1Maryam Nemati2Maryam Nemati3Prashant Chauhan4Ashok Patidar5Arup Sarkar6Iraj Sharifi7Bhaskar Saha8Bhaskar Saha9Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, IranImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranDepartment of Haematology and Laboratory Sciences, School of Para-Medicine, Kerman University of Medical Sciences, Kerman, IranNational Centre for Cell Science, Pune, IndiaNational Centre for Cell Science, Pune, IndiaTrident Academy of Creative Technology, Bhubaneswar, IndiaLeishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, IranNational Centre for Cell Science, Pune, IndiaTrident Academy of Creative Technology, Bhubaneswar, IndiaIL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathogenic reactions and tissue damages. Herein, we analyze the mechanism of the functional duality of IL-27 in the resistance or susceptibility to Leishmania infection, prompting IL-27 for anti-Leishmanial therapy.https://www.frontiersin.org/article/10.3389/fimmu.2020.01573/fullEBI3IL-27Leishmaniap28WSX-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Abdollah Jafarzadeh Abdollah Jafarzadeh Maryam Nemati Maryam Nemati Prashant Chauhan Ashok Patidar Arup Sarkar Iraj Sharifi Bhaskar Saha Bhaskar Saha |
| spellingShingle |
Abdollah Jafarzadeh Abdollah Jafarzadeh Maryam Nemati Maryam Nemati Prashant Chauhan Ashok Patidar Arup Sarkar Iraj Sharifi Bhaskar Saha Bhaskar Saha Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis Frontiers in Immunology EBI3 IL-27 Leishmania p28 WSX-1 |
| author_facet |
Abdollah Jafarzadeh Abdollah Jafarzadeh Maryam Nemati Maryam Nemati Prashant Chauhan Ashok Patidar Arup Sarkar Iraj Sharifi Bhaskar Saha Bhaskar Saha |
| author_sort |
Abdollah Jafarzadeh |
| title |
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis |
| title_short |
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis |
| title_full |
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis |
| title_fullStr |
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis |
| title_full_unstemmed |
Interleukin-27 Functional Duality Balances Leishmania Infectivity and Pathogenesis |
| title_sort |
interleukin-27 functional duality balances leishmania infectivity and pathogenesis |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Immunology |
| issn |
1664-3224 |
| publishDate |
2020-08-01 |
| description |
IL-27 is a cytokine that exerts diverse effects on the cells of innate and adaptive immune systems. Chiefly expressed in macrophages and dendritic cells during the early phase of Leishmania infection, IL-27 contributes to the protection against L. major infection but suppresses the protective Th1 response against L. donovani, L. infantum, L. amazonensis and L. braziliensis infections, suggesting its functional duality. During the late stage of Leishmania infection, IL-27 limits the immunopathogenic reactions and tissue damages. Herein, we analyze the mechanism of the functional duality of IL-27 in the resistance or susceptibility to Leishmania infection, prompting IL-27 for anti-Leishmanial therapy. |
| topic |
EBI3 IL-27 Leishmania p28 WSX-1 |
| url |
https://www.frontiersin.org/article/10.3389/fimmu.2020.01573/full |
| work_keys_str_mv |
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