THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.

THDP17 decreases ammonia production through glutaminase inhibition. A new drug for hepatic encephalopathy therapy.

Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia. Management of ammonia formation can be effective in HE treatment by lowering intestinal ammonia production. The use of glutaminase inhibitors repres...

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Main Authors: M Mar Díaz-Herrero, José A del Campo, Pilar Carbonero-Aguilar, José M Vega-Pérez, Fernando Iglesias-Guerra, Ignacio Periñán, Francisco J Miñano, Juan Bautista, Manuel Romero-Gómez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4201470?pdf=render

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