Study On Synthesis and Biological Activity of Some Pyridopyridazine Derivatives

• Main Authors: Sevilay Akçay, Mahmut Ülger, Fatma Kaynak Onurdağ, Yasemin Dündar
• Format: Article
• Language: English
• Published: Slovenian Chemical Society 2018-12-01
• Series: Acta Chimica Slovenica
• Subjects: pyrido[3,4-d]pyridazine derivatives; pyrido[3,4-d]pyridazin-4(3H)-one; pyrido[3,4-d]pyridazin-1(2H)-one; antimycobacterial activity
• Online Access: https://journals.matheo.si/index.php/ACSi/article/view/4590

In this study, new pyrido[3,4-d]pyridazine derivatives were synthesized and evaluated for their in vitro antibacterial, antifungal and antimycobacterial activities. Among the synthesized compounds, compound 10 (1-(4-benzylpiperazin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) and compound 12 (1-(4-benzylpiperidin-1-yl)pyrido[3,4-d]pyridazin-4(3H)-one) were found to have the highest antimycobacterial activity. However, all compounds were found ineffective against tested Gram-positive, Gram-negative bacteria and fungus.