Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns

We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors o...

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Main Authors:	Makino Shingo, Nakanishi Eiji, Tsuji Takashi
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Química 2003-01-01
Series:	Journal of the Brazilian Chemical Society
Subjects:	solid-phase synthesis drug quinazoline 1,2,3-benzotriazin-4-one SynPhaseTM Lantern diazotization
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019

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spelling	doaj-7391d014e74c4afdb4ffc93ebd9c168f2020-11-25T02:27:03ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532003-01-01143452455Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM LanternsMakino ShingoNakanishi EijiTsuji TakashiWe have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019solid-phase synthesisdrugquinazoline1,2,3-benzotriazin-4-oneSynPhaseTM Lanterndiazotization
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Makino Shingo Nakanishi Eiji Tsuji Takashi
spellingShingle	Makino Shingo Nakanishi Eiji Tsuji Takashi Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns Journal of the Brazilian Chemical Society solid-phase synthesis drug quinazoline 1,2,3-benzotriazin-4-one SynPhaseTM Lantern diazotization
author_facet	Makino Shingo Nakanishi Eiji Tsuji Takashi
author_sort	Makino Shingo
title	Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
title_short	Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
title_full	Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
title_fullStr	Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
title_full_unstemmed	Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
title_sort	efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with synphasetm lanterns
publisher	Sociedade Brasileira de Química
series	Journal of the Brazilian Chemical Society
issn	0103-5053
publishDate	2003-01-01
description	We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns.
topic	solid-phase synthesis drug quinazoline 1,2,3-benzotriazin-4-one SynPhaseTM Lantern diazotization
url	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019
work_keys_str_mv	AT makinoshingo efficientsolidphasesynthesisof123benzotriazin4oneswithsynphasetmlanterns AT nakanishieiji efficientsolidphasesynthesisof123benzotriazin4oneswithsynphasetmlanterns AT tsujitakashi efficientsolidphasesynthesisof123benzotriazin4oneswithsynphasetmlanterns
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Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns

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