Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns
We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2003-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532003000300019 |
| Summary: | We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various bioactivities of these derivatives. The precursors of 1,2,3-benzotriazin-4-ones, 2-aminobenzamides, were prepared from solid-supported amines and 2-nitrobenzoic acids. Various 1,2,3-benzotriazin-4-ones were obtained with high purity using SynPhaseTM Lanterns. |
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| ISSN: | 0103-5053 |