Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives

Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic...

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Main Authors:	Zenghui Ye, Yanqi Wu, Na Chen, Hong Zhang, Kai Zhu, Mingruo Ding, Min Liu, Yong Li, Fengzhi Zhang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17389-w

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spelling	doaj-738cfb6b38a84e0f990f74d1bfe7f6782021-07-25T11:39:44ZengNature Publishing GroupNature Communications2041-17232020-07-011111810.1038/s41467-020-17389-wEnantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivativesZenghui Ye0Yanqi Wu1Na Chen2Hong Zhang3Kai Zhu4Mingruo Ding5Min Liu6Yong Li7Fengzhi Zhang8College of Pharmaceutical Science, Zhejiang University of TechnologyZhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyCollege of Pharmaceutical Science, Zhejiang University of TechnologyChiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.https://doi.org/10.1038/s41467-020-17389-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang
spellingShingle	Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives Nature Communications
author_facet	Zenghui Ye Yanqi Wu Na Chen Hong Zhang Kai Zhu Mingruo Ding Min Liu Yong Li Fengzhi Zhang
author_sort	Zenghui Ye
title	Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
title_short	Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
title_full	Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
title_fullStr	Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
title_full_unstemmed	Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
title_sort	enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Chiral and hindered triazolopyridinone derivatives are an underexplored area of chemical space mainly due to their challenging synthesis via classical methods. Here, the authors report an electrochemical rearrangement for the synthesis of triazolopyridinones using diverse, available alkyl carboxylic acids as starting materials.
url	https://doi.org/10.1038/s41467-020-17389-w
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Enantiospecific electrochemical rearrangement for the synthesis of hindered triazolopyridinone derivatives

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