Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.

The fusion of monocyte/macrophage lineage cells into fully active, multinucleated, bone resorbing osteoclasts is a complex cell biological phenomenon that utilizes specialized proteins. OC-STAMP, a multi-pass transmembrane protein, has been shown to be required for pre-osteoclast fusion and for opti...

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Bibliographic Details
Main Authors: Hanna Witwicka, Sung-Yong Hwang, Pablo Reyes-Gutierrez, Hong Jia, Paul E Odgren, Leah Rae Donahue, Mark J Birnbaum, Paul R Odgren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4456411?pdf=render

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http://europepmc.org/articles/PMC4456411?pdf=render

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