Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

Synthesis and Biological Evaluation of 3-Benzisoxazolyl-4-indolylmaleimides as Potent, Selective Inhibitors of Glycogen Synthase Kinase-3β

A series of novel 3-benzisoxazolyl-4-indolyl-maleimides were synthesized and evaluated for their GSK-3β inhibitory activity. Most compounds exhibited high inhibitory potency towards GSK-3β. Among them, compound 7j with an IC50 value of 0.73 nM was the most promising GSK-3β inhibitor. Preliminary str...

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Bibliographic Details
Main Authors:	Jianrong Gao, Weisi Wang, Yujin Li, Liang Han, Lei Xu, Jiayi Cao, Tao Pang, Yubo Zhou, Meng Li, Qing Ye, Jia Li
Format:	Article
Language:	English
Published:	MDPI AG 2013-05-01
Series:	Molecules
Subjects:	3-benzisoxazolyl-4-indolylmaleimides synthesis GSK-3β biological activity docking SAR
Online Access:	http://www.mdpi.com/1420-3049/18/5/5498

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