Tunable, division-independent control of gene activation timing by a polycomb switch

Tunable, division-independent control of gene activation timing by a polycomb switch

Summary: During development, progenitors often differentiate many cell generations after receiving signals. These delays must be robust yet tunable for precise population size control. Polycomb repressive mechanisms, involving histone H3 lysine-27 trimethylation (H3K27me3), restrain the expression o...

Full description

Bibliographic Details
Main Authors: Nicholas A. Pease, Phuc H.B. Nguyen, Marcus A. Woodworth, Kenneth K.H. Ng, Blythe Irwin, Joshua C. Vaughan, Hao Yuan Kueh
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
T cell development
gene regulation
epigenetic switch
timing control
stochasticity
tunability
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002023

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721002023

Similar Items