SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract

SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract

Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes and have been identified as a potential source of antineoplastic agent with less undesirable side effects. Here, we de...

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Bibliographic Details
Main Authors: Andrea Floris, Michael Mazarei, Xi Yang, Aaron Elias Robinson, Jennifer Zhou, Antonio Barberis, Guy D’hallewin, Emanuela Azara, Ylenia Spissu, Ainhoa Iglesias-Ara, Sandro Orrù, Maria Lauda Tomasi
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Biomolecules
Subjects:
antioxidant
breast cancer
FASN
lipid metabolism
polyphenols
protein degradation
Online Access:https://www.mdpi.com/2218-273X/10/4/529

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