Level of Retinol Deposit and Cervical Cancer

Objective: To analyze level of retinol deposit sufficiency in the natural history of cervical cancer. Methods: Serum retinol level was measured by ELISA from peripheral blood of subjects with normal cervix, cleared and persistent high risk human papilloma virus (HR-HPV) subclinical infection,...

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Main Authors: Tofan W Utami, Fera Ibrahim, Gatot Purwoto, Wely L Tiffani, Muhammad F Aziz, Andrijono Andrijono
Format: Article
Language:English
Published: Indonesian Society of Obstetrics and Gynecology 2017-06-01
Series:Indonesian Journal of Obstetrics and Gynecology
Online Access:http://inajog.com/index.php/journal/article/view/465
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spelling doaj-7362467ef4e149f892915ff6a57cfe1d2021-06-02T18:14:17ZengIndonesian Society of Obstetrics and GynecologyIndonesian Journal of Obstetrics and Gynecology2338-64012338-73352017-06-01465410.32771/inajog.v5i1.465465Level of Retinol Deposit and Cervical CancerTofan W Utami0Fera Ibrahim1Gatot Purwoto2Wely L Tiffani3Muhammad F Aziz4Andrijono Andrijono5Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaObjective: To analyze level of retinol deposit sufficiency in the natural history of cervical cancer. Methods: Serum retinol level was measured by ELISA from peripheral blood of subjects with normal cervix, cleared and persistent high risk human papilloma virus (HR-HPV) subclinical infection, and cervical cancer who fulfilled the inclusion and exclusion criteria. The study was held in Dr. Cipto Mangunkusumo and Fatmawati Hospital, Jakarta, within 2 years (August 2013- 2015). Blood was taken twice, consisting of post-8-hour fasting blood and 2 hours after 6000 IU retinyl palmitate oral administration. Results: Of 47 total samples, sufficient level of retinol deposit in normal cervix, cleared and persistent HR-HPV subclinical infection, and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89), 33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically, there was no significant difference from sufficiency level of retinol deposit between normal cervix and clearance HR-HPV subclinical infection (p=0.628), normal cervix and persistent HR-HPV subclinical infection (p=0.078), normal cervix and cervical cancer (p=0.433), cervical cancer and clearance HR-HPV subclinical infection (p=1.000), cervical cancer and persistent HR-HPV subclinical infection (p=0.430), persistent and clearance HR-HPV subclinical infection group (p=0.740). Conclusion: This study proves that normal cervix group has the highest level of retinol deposit sufficiency; however, it cannot be stated that cervical cancer group has less sufficiency level. Persistent HR-HPV subclinical infection group has the lowest level of retinol deposit (OR 11.33). There is no association between sufficient level of retinol deposit and clearance of HR-HPV. [Indones J Obstet Gynecol 2017; 5-1: 46-54] Keywords: cervical cancer, HR-HPV clearance, retinol deposithttp://inajog.com/index.php/journal/article/view/465
collection DOAJ
language English
format Article
sources DOAJ
author Tofan W Utami
Fera Ibrahim
Gatot Purwoto
Wely L Tiffani
Muhammad F Aziz
Andrijono Andrijono
spellingShingle Tofan W Utami
Fera Ibrahim
Gatot Purwoto
Wely L Tiffani
Muhammad F Aziz
Andrijono Andrijono
Level of Retinol Deposit and Cervical Cancer
Indonesian Journal of Obstetrics and Gynecology
author_facet Tofan W Utami
Fera Ibrahim
Gatot Purwoto
Wely L Tiffani
Muhammad F Aziz
Andrijono Andrijono
author_sort Tofan W Utami
title Level of Retinol Deposit and Cervical Cancer
title_short Level of Retinol Deposit and Cervical Cancer
title_full Level of Retinol Deposit and Cervical Cancer
title_fullStr Level of Retinol Deposit and Cervical Cancer
title_full_unstemmed Level of Retinol Deposit and Cervical Cancer
title_sort level of retinol deposit and cervical cancer
publisher Indonesian Society of Obstetrics and Gynecology
series Indonesian Journal of Obstetrics and Gynecology
issn 2338-6401
2338-7335
publishDate 2017-06-01
description Objective: To analyze level of retinol deposit sufficiency in the natural history of cervical cancer. Methods: Serum retinol level was measured by ELISA from peripheral blood of subjects with normal cervix, cleared and persistent high risk human papilloma virus (HR-HPV) subclinical infection, and cervical cancer who fulfilled the inclusion and exclusion criteria. The study was held in Dr. Cipto Mangunkusumo and Fatmawati Hospital, Jakarta, within 2 years (August 2013- 2015). Blood was taken twice, consisting of post-8-hour fasting blood and 2 hours after 6000 IU retinyl palmitate oral administration. Results: Of 47 total samples, sufficient level of retinol deposit in normal cervix, cleared and persistent HR-HPV subclinical infection, and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89), 33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically, there was no significant difference from sufficiency level of retinol deposit between normal cervix and clearance HR-HPV subclinical infection (p=0.628), normal cervix and persistent HR-HPV subclinical infection (p=0.078), normal cervix and cervical cancer (p=0.433), cervical cancer and clearance HR-HPV subclinical infection (p=1.000), cervical cancer and persistent HR-HPV subclinical infection (p=0.430), persistent and clearance HR-HPV subclinical infection group (p=0.740). Conclusion: This study proves that normal cervix group has the highest level of retinol deposit sufficiency; however, it cannot be stated that cervical cancer group has less sufficiency level. Persistent HR-HPV subclinical infection group has the lowest level of retinol deposit (OR 11.33). There is no association between sufficient level of retinol deposit and clearance of HR-HPV. [Indones J Obstet Gynecol 2017; 5-1: 46-54] Keywords: cervical cancer, HR-HPV clearance, retinol deposit
url http://inajog.com/index.php/journal/article/view/465
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