Level of Retinol Deposit and Cervical Cancer
Objective: To analyze level of retinol deposit sufficiency in the natural history of cervical cancer. Methods: Serum retinol level was measured by ELISA from peripheral blood of subjects with normal cervix, cleared and persistent high risk human papilloma virus (HR-HPV) subclinical infection,...
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2017-06-01
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doaj-7362467ef4e149f892915ff6a57cfe1d2021-06-02T18:14:17ZengIndonesian Society of Obstetrics and GynecologyIndonesian Journal of Obstetrics and Gynecology2338-64012338-73352017-06-01465410.32771/inajog.v5i1.465465Level of Retinol Deposit and Cervical CancerTofan W Utami0Fera Ibrahim1Gatot Purwoto2Wely L Tiffani3Muhammad F Aziz4Andrijono Andrijono5Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaFaculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Hospital JakartaObjective: To analyze level of retinol deposit sufficiency in the natural history of cervical cancer. Methods: Serum retinol level was measured by ELISA from peripheral blood of subjects with normal cervix, cleared and persistent high risk human papilloma virus (HR-HPV) subclinical infection, and cervical cancer who fulfilled the inclusion and exclusion criteria. The study was held in Dr. Cipto Mangunkusumo and Fatmawati Hospital, Jakarta, within 2 years (August 2013- 2015). Blood was taken twice, consisting of post-8-hour fasting blood and 2 hours after 6000 IU retinyl palmitate oral administration. Results: Of 47 total samples, sufficient level of retinol deposit in normal cervix, cleared and persistent HR-HPV subclinical infection, and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89), 33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically, there was no significant difference from sufficiency level of retinol deposit between normal cervix and clearance HR-HPV subclinical infection (p=0.628), normal cervix and persistent HR-HPV subclinical infection (p=0.078), normal cervix and cervical cancer (p=0.433), cervical cancer and clearance HR-HPV subclinical infection (p=1.000), cervical cancer and persistent HR-HPV subclinical infection (p=0.430), persistent and clearance HR-HPV subclinical infection group (p=0.740). Conclusion: This study proves that normal cervix group has the highest level of retinol deposit sufficiency; however, it cannot be stated that cervical cancer group has less sufficiency level. Persistent HR-HPV subclinical infection group has the lowest level of retinol deposit (OR 11.33). There is no association between sufficient level of retinol deposit and clearance of HR-HPV. [Indones J Obstet Gynecol 2017; 5-1: 46-54] Keywords: cervical cancer, HR-HPV clearance, retinol deposithttp://inajog.com/index.php/journal/article/view/465 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tofan W Utami Fera Ibrahim Gatot Purwoto Wely L Tiffani Muhammad F Aziz Andrijono Andrijono |
spellingShingle |
Tofan W Utami Fera Ibrahim Gatot Purwoto Wely L Tiffani Muhammad F Aziz Andrijono Andrijono Level of Retinol Deposit and Cervical Cancer Indonesian Journal of Obstetrics and Gynecology |
author_facet |
Tofan W Utami Fera Ibrahim Gatot Purwoto Wely L Tiffani Muhammad F Aziz Andrijono Andrijono |
author_sort |
Tofan W Utami |
title |
Level of Retinol Deposit and Cervical Cancer |
title_short |
Level of Retinol Deposit and Cervical Cancer |
title_full |
Level of Retinol Deposit and Cervical Cancer |
title_fullStr |
Level of Retinol Deposit and Cervical Cancer |
title_full_unstemmed |
Level of Retinol Deposit and Cervical Cancer |
title_sort |
level of retinol deposit and cervical cancer |
publisher |
Indonesian Society of Obstetrics and Gynecology |
series |
Indonesian Journal of Obstetrics and Gynecology |
issn |
2338-6401 2338-7335 |
publishDate |
2017-06-01 |
description |
Objective: To analyze level of retinol deposit sufficiency in the
natural history of cervical cancer.
Methods: Serum retinol level was measured by ELISA from
peripheral blood of subjects with normal cervix, cleared and
persistent high risk human papilloma virus (HR-HPV) subclinical
infection, and cervical cancer who fulfilled the inclusion and
exclusion criteria. The study was held in Dr. Cipto Mangunkusumo
and Fatmawati Hospital, Jakarta, within 2 years (August 2013-
2015). Blood was taken twice, consisting of post-8-hour fasting
blood and 2 hours after 6000 IU retinyl palmitate oral
administration.
Results: Of 47 total samples, sufficient level of retinol deposit in
normal cervix, cleared and persistent HR-HPV subclinical infection,
and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89),
33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically,
there was no significant difference from sufficiency level of retinol
deposit between normal cervix and clearance HR-HPV subclinical
infection (p=0.628), normal cervix and persistent HR-HPV
subclinical infection (p=0.078), normal cervix and cervical cancer
(p=0.433), cervical cancer and clearance HR-HPV subclinical
infection (p=1.000), cervical cancer and persistent HR-HPV
subclinical infection (p=0.430), persistent and clearance HR-HPV
subclinical infection group (p=0.740).
Conclusion: This study proves that normal cervix group has the
highest level of retinol deposit sufficiency; however, it cannot
be stated that cervical cancer group has less sufficiency level.
Persistent HR-HPV subclinical infection group has the lowest
level of retinol deposit (OR 11.33). There is no association
between sufficient level of retinol deposit and clearance of
HR-HPV.
[Indones J Obstet Gynecol 2017; 5-1: 46-54]
Keywords: cervical cancer, HR-HPV clearance, retinol deposit |
url |
http://inajog.com/index.php/journal/article/view/465 |
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