The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex

The C. elegans homolog of human panic-disorder risk gene TMEM132D orchestrates neuronal morphogenesis through the WAVE-regulatory complex

Abstract TMEM132D is a human gene identified with multiple risk alleles for panic disorders, anxiety and major depressive disorders. Defining a conserved family of transmembrane proteins, TMEM132D and its homologs are still of unknown molecular functions. By generating loss-of-function mutants of th...

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Bibliographic Details
Main Authors: Xin Wang, Wei Jiang, Shuo Luo, Xiaoyu Yang, Changnan Wang, Bingying Wang, Yongjun Dang, Yin Shen, Dengke K. Ma
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Brain
Subjects:
TMEM132D
Panic disorder
WAVE regulatory complex
Actin
C. elegans
Online Access:https://doi.org/10.1186/s13041-021-00767-w

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