Two New Diterpenoids from Biscogniauxia sp. and Their Activities
Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2021.749272/full |
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doaj-7356667cf9ed4ef0af5833e95628683d2021-09-04T01:19:55ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462021-09-01910.3389/fchem.2021.749272749272Two New Diterpenoids from Biscogniauxia sp. and Their ActivitiesHuan Zhao0Yue Liu1Meng Zhang2Guo-dong Chen3Dan Hu4Liang-dong Guo5Zhong-xiang Zhao6Hui Zhi7Hao Gao8College of Traditional Chinese Medicine, Jinan University, Guangzhou, ChinaInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, ChinaInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, ChinaTwo new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.https://www.frontiersin.org/articles/10.3389/fchem.2021.749272/fullBiscogniauxia spditerpenoidsisopimarane typeabietane typeAlzheimer’s disease |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Huan Zhao Yue Liu Meng Zhang Guo-dong Chen Dan Hu Liang-dong Guo Zhong-xiang Zhao Hui Zhi Hao Gao |
| spellingShingle |
Huan Zhao Yue Liu Meng Zhang Guo-dong Chen Dan Hu Liang-dong Guo Zhong-xiang Zhao Hui Zhi Hao Gao Two New Diterpenoids from Biscogniauxia sp. and Their Activities Frontiers in Chemistry Biscogniauxia sp diterpenoids isopimarane type abietane type Alzheimer’s disease |
| author_facet |
Huan Zhao Yue Liu Meng Zhang Guo-dong Chen Dan Hu Liang-dong Guo Zhong-xiang Zhao Hui Zhi Hao Gao |
| author_sort |
Huan Zhao |
| title |
Two New Diterpenoids from Biscogniauxia sp. and Their Activities |
| title_short |
Two New Diterpenoids from Biscogniauxia sp. and Their Activities |
| title_full |
Two New Diterpenoids from Biscogniauxia sp. and Their Activities |
| title_fullStr |
Two New Diterpenoids from Biscogniauxia sp. and Their Activities |
| title_full_unstemmed |
Two New Diterpenoids from Biscogniauxia sp. and Their Activities |
| title_sort |
two new diterpenoids from biscogniauxia sp. and their activities |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Chemistry |
| issn |
2296-2646 |
| publishDate |
2021-09-01 |
| description |
Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD. |
| topic |
Biscogniauxia sp diterpenoids isopimarane type abietane type Alzheimer’s disease |
| url |
https://www.frontiersin.org/articles/10.3389/fchem.2021.749272/full |
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