Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Two New Diterpenoids from Biscogniauxia sp. and Their Activities

Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD...

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Bibliographic Details
Main Authors: Huan Zhao, Yue Liu, Meng Zhang, Guo-dong Chen, Dan Hu, Liang-dong Guo, Zhong-xiang Zhao, Hui Zhi, Hao Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Chemistry
Subjects:
Biscogniauxia sp
diterpenoids
isopimarane type
abietane type
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.749272/full
Description
Summary:Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, 13C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.
ISSN:2296-2646

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