Targeting the Oncogenic TBX2 Transcription Factor With Chromomycins

Targeting the Oncogenic TBX2 Transcription Factor With Chromomycins

The TBX2 transcription factor plays critical roles during embryonic development and it is overexpressed in several cancers, where it contributes to key oncogenic processes including the promotion of proliferation and bypass of senescence. Importantly, based on compelling biological evidences, TBX2 h...

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Bibliographic Details
Main Authors: Bianca Del B. Sahm, Jade Peres, Paula Rezende-Teixeira, Evelyne A. Santos, Paola C. Branco, Anelize Bauermeister, Serah Kimani, Eduarda A. Moreira, Renata Bisi-Alves, Claire Bellis, Mihlali Mlaza, Paula C. Jimenez, Norberto P. Lopes, Glaucia M. Machado-Santelli, Sharon Prince, Leticia V. Costa-Lotufo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Chemistry
Subjects:
DNA-binding agents
T-box factors
reverse affinity
microscale thermophoresis
melanoma
chromomycins
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00110/full

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