PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation.

PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation.

BACKGROUND:Abnormal trophoblast differentiation and function is the basis of many placenta-based pregnancy disorders, including pre-eclampsia and fetal growth restriction. PPARgamma, a ligand-activated nuclear receptor, plays essential roles in placental development; null murine embryos die at midge...

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Bibliographic Details
Main Authors: Mana M Parast, Heather Yu, Aleksandar Ciric, Mark W Salata, Vannessa Davis, David S Milstone
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-11-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2778869?pdf=render

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