Frequency and association of 1691 (G>A) FVL, 20210 (G>A) PT and 677 (C>T) MTHFR with deep vein thrombosis in the population of Bosnia and Herzegovina

• Main Authors: Jusić-Karić A, Terzić R, Jerkić Z, Avdić A, Pođanin M
• Format: Article
• Language: English
• Published: Sciendo 2016-06-01
• Series: Balkan Journal of Medical Genetics
• Subjects: 1691 (g>a) factor v leiden (fvl); 20210 (g>a) prothrombin (pt); 677 (c>t) methylene tetrahydrofolate reductase (mthfr)
• Online Access: https://doi.org/10.1515/bjmg-2016-0006

The 1691 (G>A) factor V Leiden (FVL) and 20210 (G>A) prothrombin (PT) mutations are the two most common genetic risk factors in venous thromboembolism. The 677 (C>T) methylene tetrahydrofolate reductase (MTHFR) mutation is the most frequently mentioned as an independent genetic risk factor for venous thromboembolism. As there are limited published data on the prevalence of the 1691, 20210 and 677 mutations in our population, the aim of this study was to determine the frequencies and association of these deep vein thrombosis mutations in the Bosnian population.