Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

Development of a Physiologically Based Pharmacokinetic Model for Hydroxychloroquine and Its Application in Dose Optimization in Specific COVID-19 Patients

In Feb 2020, we developed a physiologically-based pharmacokinetic (PBPK) model of hydroxychloroquine (HCQ) and integrated in vitro anti-viral effect to support dosing design of HCQ in the treatment of COVID-19 patients in China. This, along with emerging research and clinical findings, supported bro...

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Bibliographic Details
Main Authors: Miao Zhang, Xueting Yao, Zhe Hou, Xuan Guo, Siqi Tu, Zihan Lei, Zhiheng Yu, Xuanlin Liu, Cheng Cui, Xijing Chen, Ning Shen, Chunli Song, Jie Qiao, Xiaoqiang Xiang, Haiyan Li, Dongyang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
hydroxychloroquine
physiologically-based pharmacokinetic
drug-drug interaction
specific populations
dosing recommendation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.585021/full

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