Immune Heterogeneity Between Primary Tumors and Corresponding Metastatic Lesions and Response to Platinum Therapy in Primary Ovarian Cancer

Immune Heterogeneity Between Primary Tumors and Corresponding Metastatic Lesions and Response to Platinum Therapy in Primary Ovarian Cancer

CD3<sup>+</sup> and CD8<sup>+</sup> lymphocytes are well known prognostic markers in primary ovarian cancer. In contrast, the predictive value of the immune infiltrate concerning treatment response and the involvement of immune heterogeneity between primary and metastatic les...

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Bibliographic Details
Main Authors: Katharina Dötzer, Friederike Schlüter, Markus Bo Schoenberg, Alexandr V. Bazhin, Franz Edler von Koch, Andreas Schnelzer, Sabine Anthuber, Dieter Grab, Bastian Czogalla, Alexander Burges, Jens Werner, Sven Mahner, Barbara Mayer
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
ovarian cancer
metastatic lesions
tumor microenvironment
TILs
immune heterogeneity
platinum-sensitivity
immune checkpoints
Online Access:https://www.mdpi.com/2072-6694/11/9/1250

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