Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy

Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy

Abstract SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of...

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Main Authors: Gregory P. Westcott, Alissa R. Segal, Joanna Mitri, Florence M. Brown
Format: Article
Language:English
Published: Wiley 2020-04-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
diabetic ketoacidosis
inpatient diabetes management
prolonged glucosuria
SGLT2 inhibitors
Online Access:https://doi.org/10.1002/edm2.117
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spelling doaj-731b0666b80b4e56a8e791f4f9b9f85d2020-11-25T02:07:41ZengWileyEndocrinology, Diabetes & Metabolism2398-92382020-04-0132n/an/a10.1002/edm2.117Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapyGregory P. Westcott0Alissa R. Segal1Joanna Mitri2Florence M. Brown3Joslin Diabetes Center Boston MassachusettsJoslin Diabetes Center Boston MassachusettsJoslin Diabetes Center Boston MassachusettsJoslin Diabetes Center Boston MassachusettsAbstract SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of glucosuria and inpatient course of SGLT2i‐related DKA, however, is not well‐characterized. We report 11 inpatient cases of SGLT2i‐related DKA, including a subset of patients who experienced prolonged glucosuria and relapse of DKA during their hospitalization.https://doi.org/10.1002/edm2.117diabetic ketoacidosisinpatient diabetes managementprolonged glucosuriaSGLT2 inhibitors
collection DOAJ
language English
format Article
sources DOAJ
author Gregory P. Westcott
Alissa R. Segal
Joanna Mitri
Florence M. Brown
spellingShingle Gregory P. Westcott
Alissa R. Segal
Joanna Mitri
Florence M. Brown
Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
Endocrinology, Diabetes & Metabolism
diabetic ketoacidosis
inpatient diabetes management
prolonged glucosuria
SGLT2 inhibitors
author_facet Gregory P. Westcott
Alissa R. Segal
Joanna Mitri
Florence M. Brown
author_sort Gregory P. Westcott
title Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_short Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_full Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_fullStr Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_full_unstemmed Prolonged glucosuria and relapse of diabetic ketoacidosis related to SGLT2‐inhibitor therapy
title_sort prolonged glucosuria and relapse of diabetic ketoacidosis related to sglt2‐inhibitor therapy
publisher Wiley
series Endocrinology, Diabetes & Metabolism
issn 2398-9238
publishDate 2020-04-01
description Abstract SGLT2 inhibitors (SGLT2i) are glucose‐lowering medications which increase the renal threshold for glucose reabsorption and promote glucosuria. Treatment with these agents raises serum ketone levels, and cases of diabetic ketoacidosis (DKA) during therapy have been reported. The duration of glucosuria and inpatient course of SGLT2i‐related DKA, however, is not well‐characterized. We report 11 inpatient cases of SGLT2i‐related DKA, including a subset of patients who experienced prolonged glucosuria and relapse of DKA during their hospitalization.
topic diabetic ketoacidosis
inpatient diabetes management
prolonged glucosuria
SGLT2 inhibitors
url https://doi.org/10.1002/edm2.117
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AT joannamitri prolongedglucosuriaandrelapseofdiabeticketoacidosisrelatedtosglt2inhibitortherapy
AT florencembrown prolongedglucosuriaandrelapseofdiabeticketoacidosisrelatedtosglt2inhibitortherapy
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