FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis

FcγRIIb Expression Is Decreased on Naive and Marginal Zone-Like B Cells From Females With Multiple Sclerosis

B cells are critical to the development of multiple sclerosis (MS), but the mechanisms by which they contribute to the disease are poorly defined. We hypothesised that the expression of CD32b (FcγRIIb), a receptor for the Fc region of IgG with inhibitory activities in B cells, is lower on B cell sub...

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Bibliographic Details
Main Authors: Stephanie Trend, Jonatan Leffler, Ingrid Teige, Björn Frendéus, Allan G. Kermode, Martyn A. French, Prue H. Hart
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
multiple sclerosis
B cells
FcγRIIb
females
Epstein-Barr virus
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.614492/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.614492/full

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