Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages

Alpha-Lipoic Acid Suppresses Extracellular Histone-Induced Release of the Infammatory Mediator Tumor Necrosis Factor-α by Macrophages

Background/Aims: This study investigated signaling pathways via which extracellular histones induce the pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) release from the macrophage cell line RAW 264.7 and the anti-inflammatory efficacy of the antioxidant alpha-lipoic acid (ALA). Methods: EL...

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Bibliographic Details
Main Authors: Ping Chang, Juan Liu, Ying Yu, Shao-Ye Cui, Zhen-Hui Guo, Gui-Ming Chen, Qiong Huang, Zhan-Guo Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Extracellular histones
ALA
TNF-α
MAPKs
NF-κB
Macrophages
Online Access:http://www.karger.com/Article/FullText/480217

Internet

http://www.karger.com/Article/FullText/480217

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