Intrachromosomal amplification of chromosome 21 (iAMP21) detected by ETV6/RUNX1 FISH screening in childhood acute lymphoblastic leukemia: a case report

Intrachromosomal amplification of chromosome 21 (iAMP21) detected by ETV6/RUNX1 FISH screening in childhood acute lymphoblastic leukemia: a case report

Chromosome abnormalities that usually define high-risk acute lymphoblastic leukemia are the t(9;22)/ breakpoint cluster region protein-Abelson murine leukemia viral oncogene homolog 1, hypodiploid with < 44 chromosomes and 11q23/ myeloid/lymphoid leukemia gene rearrangements. The spectrum of acut...

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Bibliographic Details
Main Authors: Daniela Ribeiro Ney Garcia, Alejandro Mauricio Arancibia, Raul C. Ribeiro, Marcelo Gerardin Poirot Land, Maria Luiza Macedo Silva
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Leukemia, lymphoid
In situ hybridization, fluorescence
Gene amplification
Leukemia, B-cell
Chromosomes, human, pair 21/genetics
Transcription factors
Case reports
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500369&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000500369&lng=en&tlng=en

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