Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection

Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection

Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview...

Full description

Bibliographic Details
Main Authors: Nathan K Ho, Aleah C Henry, Kathene Johnson-Henry, Philip M Sherman
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2013/138673
id doaj-72ec26a3e6b34eabb8b67351ea2f4062
record_format Article
spelling doaj-72ec26a3e6b34eabb8b67351ea2f40622020-11-24T22:34:15ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79002013-01-0127528128510.1155/2013/138673Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 InfectionNathan K Ho0Aleah C Henry1Kathene Johnson-Henry2Philip M Sherman3Department of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, CanadaDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaDepartment of Paediatrics, Hospital for Sick Children, University of Toronto, Toronto, CanadaEnterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.http://dx.doi.org/10.1155/2013/138673
collection DOAJ
language English
format Article
sources DOAJ
author Nathan K Ho
Aleah C Henry
Kathene Johnson-Henry
Philip M Sherman
spellingShingle Nathan K Ho
Aleah C Henry
Kathene Johnson-Henry
Philip M Sherman
Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
Canadian Journal of Gastroenterology
author_facet Nathan K Ho
Aleah C Henry
Kathene Johnson-Henry
Philip M Sherman
author_sort Nathan K Ho
title Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
title_short Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
title_full Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
title_fullStr Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
title_full_unstemmed Pathogenicity, Host Responses and Implications for Management of Enterohemorrhagic Escherichia coli O157:H7 Infection
title_sort pathogenicity, host responses and implications for management of enterohemorrhagic escherichia coli o157:h7 infection
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 2013-01-01
description Enterohemorrhagic Escherichia coli serotype O157:H7 is a food- and waterborne pathogen that causes significant morbidity and mortality in both developing and industrialized nations. The present review focuses on the history, epidemiology and evolution of the pathogen; provides a mechanistic overview of major virulence factors (including Shiga toxins, locus of enterocyte effacement pathogenicity island and pO157 plasmid); discusses host immune responses to infection; considers available animal models; and provides an overview of current and potential future management considerations.
url http://dx.doi.org/10.1155/2013/138673
work_keys_str_mv AT nathankho pathogenicityhostresponsesandimplicationsformanagementofenterohemorrhagicescherichiacolio157h7infection
AT aleahchenry pathogenicityhostresponsesandimplicationsformanagementofenterohemorrhagicescherichiacolio157h7infection
AT kathenejohnsonhenry pathogenicityhostresponsesandimplicationsformanagementofenterohemorrhagicescherichiacolio157h7infection
AT philipmsherman pathogenicityhostresponsesandimplicationsformanagementofenterohemorrhagicescherichiacolio157h7infection
_version_ 1725728548818255872

Similar Items