TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma

TCA Cycle Rewiring as Emerging Metabolic Signature of Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is a common malignancy. Despite progress in treatment, HCC is still one of the most lethal cancers. Therefore, deepening molecular mechanisms underlying HCC pathogenesis and development is required to uncover new therapeutic strategies. Metabolic reprogramming is emerg...

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Bibliographic Details
Main Authors: Simona Todisco, Paolo Convertini, Vito Iacobazzi, Vittoria Infantino
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Cancers
Subjects:
tricarboxylic acid (tca) cycle rewiring
metabolic reprogramming
hepatocellular carcinoma (hcc)
malate/aspartate shuttle (mas)
citrate/pyruvate shuttle
glutamine
nf-κb
hif1
Online Access:https://www.mdpi.com/2072-6694/12/1/68

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