Progress in research on paclitaxel and tumor immunotherapy

Abstract Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic...

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Main Authors:	Linyan Zhu, Liqun Chen
Format:	Article
Language:	English
Published:	BMC 2019-06-01
Series:	Cellular & Molecular Biology Letters
Subjects:	Paclitaxel Anticancer mechanism Endophytic fungus Biosynthetic pathway
Online Access:	http://link.springer.com/article/10.1186/s11658-019-0164-y

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spelling	doaj-72e57fedb75042939f1e136ce0fb65062021-04-02T15:54:34ZengBMCCellular & Molecular Biology Letters1425-81531689-13922019-06-0124111110.1186/s11658-019-0164-yProgress in research on paclitaxel and tumor immunotherapyLinyan Zhu0Liqun Chen1College of Biological Science and Engineering, Fuzhou UniversityCollege of Biological Science and Engineering, Fuzhou UniversityAbstract Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments.http://link.springer.com/article/10.1186/s11658-019-0164-yPaclitaxelAnticancer mechanismEndophytic fungusBiosynthetic pathway
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Linyan Zhu Liqun Chen
spellingShingle	Linyan Zhu Liqun Chen Progress in research on paclitaxel and tumor immunotherapy Cellular & Molecular Biology Letters Paclitaxel Anticancer mechanism Endophytic fungus Biosynthetic pathway
author_facet	Linyan Zhu Liqun Chen
author_sort	Linyan Zhu
title	Progress in research on paclitaxel and tumor immunotherapy
title_short	Progress in research on paclitaxel and tumor immunotherapy
title_full	Progress in research on paclitaxel and tumor immunotherapy
title_fullStr	Progress in research on paclitaxel and tumor immunotherapy
title_full_unstemmed	Progress in research on paclitaxel and tumor immunotherapy
title_sort	progress in research on paclitaxel and tumor immunotherapy
publisher	BMC
series	Cellular & Molecular Biology Letters
issn	1425-8153 1689-1392
publishDate	2019-06-01
description	Abstract Paclitaxel is a well-known anticancer agent with a unique mechanism of action. It is considered to be one of the most successful natural anticancer drugs available. This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments.
topic	Paclitaxel Anticancer mechanism Endophytic fungus Biosynthetic pathway
url	http://link.springer.com/article/10.1186/s11658-019-0164-y
work_keys_str_mv	AT linyanzhu progressinresearchonpaclitaxelandtumorimmunotherapy AT liqunchen progressinresearchonpaclitaxelandtumorimmunotherapy
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Progress in research on paclitaxel and tumor immunotherapy

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