Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer

Insights into Telomerase/hTERT Alternative Splicing Regulation Using Bioinformatics and Network Analysis in Cancer

The reactivation of telomerase in cancer cells remains incompletely understood. The catalytic component of telomerase, <i>hTERT</i>, is thought to be the limiting component in cancer cells for the formation of active enzymes. <i>hTERT</i> gene expression is regulated at sever...

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Bibliographic Details
Main Authors: Andrew T. Ludlow, Aaron L. Slusher, Mohammed E. Sayed
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
<i>hTERT</i>
telomerase
telomeres
alternative splicing
network analysis
hierarchical clustering analysis
differential gene expression analysis
Online Access:https://www.mdpi.com/2072-6694/11/5/666

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