Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy

Simultaneous quantification method for 5-FU, uracil, and tegafur using UPLC-MS/MS and clinical application in monitoring UFT/LV combination therapy after hepatectomy

Abstract Combination therapy of tegafur/uracil (UFT) and leucovorin (LV) is widely used to treat colorectal cancers. Although this therapy has a significant therapeutic effect, severe adverse effects occur frequently. Therapeutic drug monitoring (TDM) may help to prevent adverse effects. A useful as...

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Bibliographic Details
Main Authors:	Ken Shiraiwa, Yosuke Suzuki, Hiroki Uchida, Yukio Iwashita, Ryota Tanaka, Motoshi Iwao, Kazuhiro Tada, Teijiro Hirashita, Takashi Masuda, Yuichi Endo, Masafumi Inomata, Hiroki Itoh
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-02-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-82908-8

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