Biological Redundancy of Endogenous GPCR Ligands in the Gut and the Potential for Endogenous Functional Selectivity

This review focuses on the existence and function of multiple endogenous agonists of the somatostatin and opioid receptors with an emphasis on their expression in the gastrointestinal tract (GIT). These agonists generally arise from the proteolytic cleavage of prepropeptides during peptide maturatio...

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Bibliographic Details
Main Authors: Georgina eThompson, Meritxell eCanals, Daniel Philip Poole
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00262/full