Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma

Involvement of 27-Hydroxycholesterol in Mitotane Action on Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis. Mitotane, the standard treatment for ACC, impairs adrenocortical steroid biosynthesis and cholesterol metabolism. In the H295R cell line, a standard ACC in vitro model, mitotane was previously reported to enhance the production of...

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Bibliographic Details
Main Authors: Antonina Germano, Daniela Rossin, Valerio Leoni, Noemi Iaia, Laura Saba, Vittoria Basile, Soraya Puglisi, Claudio Caccia, Giuseppe Poli, Fiorella Biasi, Massimo Terzolo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
mitotane
adrenocortical carcinoma
cholesterol metabolism
27-hydroxycholesterol
oxysterols
cytotoxicity
Online Access:https://www.mdpi.com/2073-4409/9/4/885

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