Immune response modulation by Vitamin D: role in systemic lupus erythematosus.

• Main Authors: Mirentxu eIruretagoyena, Daniela eHirigoyen, Rodrigo eNaves, Paula Isabel Burgos
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2015-10-01
• Series: Frontiers in Immunology
• Subjects: Autoimmune Diseases; Vitamin D; Immune Regulation; systemic lupus erythematosus; supplementation
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00513/full
• ISSN: 1664-3224

Vitamin D plays key roles as a natural immune modulator and has been implicated in the pathophysiology of autoimmune diseases, including systemic lupus erythematosus (SLE). This review presents a summary and analysis of the recent literature regarding immunoregulatory effects of vitamin D as well as its importance in SLE development, clinical severity and possible effects of supplementation in disease treatment.