Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

Gene amplification and/or overexpression of the transcription factor c-MYC, which binds to the E-box sequence (5′-CACGTG-3′), has been observed in many human tumors. In this study, we have designed 5 pyrrole–imidazole (PI) polyamides recognizing E-box, and found that, among them, Myc-6 significantly...

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Bibliographic Details
Main Authors: Masashi Taniguchi, Kyoko Fujiwara, Yuji Nakai, Toshinori Ozaki, Nobuko Koshikawa, Kojima Toshio, Motoaki Kataba, Asako Oguni, Hiroyuki Matsuda, Yukihiro Yoshida, Yasuaki Tokuhashi, Noboru Fukuda, Takahiro Ueno, Masayoshi Soma, Hiroki Nagase
Format: Article
Language:English
Published: Wiley 2014-01-01
Series:FEBS Open Bio
Subjects:
c-MYC
E-box
MALAT1
MG63 cells
Osteosarcoma
Pyrrole–imidazole polyamide
Online Access:http://www.sciencedirect.com/science/article/pii/S2211546314000278

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