Adenosine A<sub>2B</sub> receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity

Adenosine A<sub>2B</sub> receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity

<p>Abstract</p> <p>Background</p> <p>Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported. In the central nervous system (CNS), astrocytes are the major source for LIF, expression of which is enhanced following distur...

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Bibliographic Details
Main Authors: Moidunny Shamsudheen, Vinet Jonathan, Wesseling Evelyn, Bijzet Johan, Shieh Chu-Hsin, van Ijzendoorn Sven CD, Bezzi Paola, Boddeke Hendrikus WGM, Biber Knut
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Journal of Neuroinflammation
Subjects:
5′-N-Ethylcarboxamide (NECA)
Leukemia inhibitory factor
Neuroprotection
Glutamate
Online Access:http://www.jneuroinflammation.com/content/9/1/198

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