Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2

Frequency and Clinical Implication of the R450H Mutation in the Thyrotropin Receptor Gene in the Japanese Population Detected by Smart Amplification Process 2

In Japanese pediatric patients with thyrotropin (TSH) resistance, the R450H mutation in TSH receptor gene (TSHR) is occasionally observed. We studied the frequency and clinical implication of the R450H mutation in TSHR in the general population of Japanese adults using smart amplification process 2...

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Bibliographic Details
Main Authors: Katsuhiko Tsunekawa, Yoshimaro Yanagawa, Tomoyuki Aoki, Tadashi Morimura, Osamu Araki, Takao Kimura, Takayuki Ogiwara, Nobuo Kotajima, Masumi Yanagawa, Masami Murakami
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/964635

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