Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67: a unique subtype

Large cell neuroendocrine carcinoma with a solitary brain metastasis and low Ki-67: a unique subtype

Introduction: Stage IV large cell neuroendocrine carcinoma (LCNEC) of the lung generally presents as disseminated and aggressive disease with a Ki-67 proliferation index (PI) 40–80%. LCNEC can be subdivided in two main subtypes: the first harboring TP53/RB1 mutations (small-cell lung carcinoma (SCLC...

Full description

Bibliographic Details
Main Authors: B C M Hermans, J L Derks, H J M Groen, J A Stigt, R J van Suylen, L M Hillen, E C van den Broek, E J M Speel, A-M C Dingemans
Format: Article
Language:English
Published: Bioscientifica 2019-12-01
Series:Endocrine Connections
Subjects:
large cell neuroendocrine carcinoma
lcnec
solitary brain metastasis
prognosis
ki-67
Online Access:https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-0372/ec-19-0372.xml

Internet

https://ec.bioscientifica.com/view/journals/ec/aop/ec-19-0372/ec-19-0372.xml

Similar Items