The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.

PrP(Sc), a misfolded and aggregated form of the cellular prion protein PrP(C), is the only defined constituent of the transmissible agent causing prion diseases. Expression of PrP(C) in the host organism is necessary for prion replication and for prion neurotoxicity. Understanding prion diseases nec...

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Bibliographic Details
Main Authors: Magdalini Polymenidou, Rita Moos, Mike Scott, Christina Sigurdson, Yong-Zhong Shi, Bill Yajima, Iva Hafner-Bratkovic, Roman Jerala, Simone Hornemann, Kurt Wuthrich, Anne Bellon, Martin Vey, Graciela Garen, Michael N G James, Nat Kav, Adriano Aguzzi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2592702?pdf=render

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http://europepmc.org/articles/PMC2592702?pdf=render

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