Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension

Pulmonary Artery Smooth Muscle Cell Senescence Promotes the Proliferation of PASMCs by Paracrine IL-6 in Hypoxia-Induced Pulmonary Hypertension

Pulmonary hypertension (PH) is a critical and dangerous disease in cardiovascular system. Pulmonary vascular remodeling is an important pathophysiological mechanism for the development of pulmonary arterial hypertension. Pulmonary artery smooth muscle cell (PASMC) proliferation, hypertrophy, and enh...

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Bibliographic Details
Main Authors: Ai-Ping Wang, Fang Yang, Ying Tian, Jian-Hui Su, Qing Gu, Wei Chen, Shao-Xin Gong, Xiao-Feng Ma, Xu-Ping Qin, Zhi-Sheng Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Physiology
Subjects:
pulmonary artery smooth muscle cells senescence
interleukin-6 (IL-6)
mTOR- S6K1 signaling
pulmonary hypertension
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.656139/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.656139/full

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