Synergistic Interaction of Histone Deacetylase 6- and MEK-Inhibitors in Castration-Resistant Prostate Cancer Cells

Synergistic Interaction of Histone Deacetylase 6- and MEK-Inhibitors in Castration-Resistant Prostate Cancer Cells

In spite of new knowledge on prostate cancer molecular landscape, this has been only partially translated to the therapeutic setting. The activation of Ras/Mitogen-activated protein kinase (MAPK) signaling plays an important role in progression of prostate cancer in which deregulation of histone dea...

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Bibliographic Details
Main Authors: Cristina Corno, Noemi Arrighetti, Emilio Ciusani, Elisabetta Corna, Nives Carenini, Nadia Zaffaroni, Laura Gatti, Paola Perego
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
prostate cancer
castration-resistance
ricolinostat
selumetinib
paclitaxel
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00610/full

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