Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma

Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma

Esophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicate...

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Main Authors: Hidetaka Sugihara, Takatsugu Ishimoto, Keisuke Miyake, Daisuke Izumi, Yoshifumi Baba, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
esophageal squamous cell carcinoma
microRNA
long noncoding RNA
cancer initiation
cancer development
biomarker
Online Access:http://www.mdpi.com/1422-0067/16/11/26060
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spelling doaj-727da3e5f7b644ec9aa9a5815b7f6cbf2020-11-25T01:08:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672015-11-011611278242783410.3390/ijms161126060ijms161126060Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell CarcinomaHidetaka Sugihara0Takatsugu Ishimoto1Keisuke Miyake2Daisuke Izumi3Yoshifumi Baba4Naoya Yoshida5Masayuki Watanabe6Hideo Baba7Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanDepartment of Gastroenterological Surgery, The Cancer Institute Hospital of Japanese Foundation For Cancer Research (JFCR), Tokyo 135-8550, JapanDepartment of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto 860-8556, JapanEsophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicated in various physiological processes. Unambiguous evidence indicates that dysregulation of ncRNAs is deeply implicated in carcinogenesis, cancer progression and metastases of various cancers, including ESCC. The current review summarizes recent findings on the ncRNA-mediated mechanisms underlying the characteristic behaviors of ESCC that will help support the development of biomarkers and the design of novel therapeutic strategies.http://www.mdpi.com/1422-0067/16/11/26060esophageal squamous cell carcinomamicroRNAlong noncoding RNAcancer initiationcancer developmentbiomarker
collection DOAJ
language English
format Article
sources DOAJ
author Hidetaka Sugihara
Takatsugu Ishimoto
Keisuke Miyake
Daisuke Izumi
Yoshifumi Baba
Naoya Yoshida
Masayuki Watanabe
Hideo Baba
spellingShingle Hidetaka Sugihara
Takatsugu Ishimoto
Keisuke Miyake
Daisuke Izumi
Yoshifumi Baba
Naoya Yoshida
Masayuki Watanabe
Hideo Baba
Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
International Journal of Molecular Sciences
esophageal squamous cell carcinoma
microRNA
long noncoding RNA
cancer initiation
cancer development
biomarker
author_facet Hidetaka Sugihara
Takatsugu Ishimoto
Keisuke Miyake
Daisuke Izumi
Yoshifumi Baba
Naoya Yoshida
Masayuki Watanabe
Hideo Baba
author_sort Hidetaka Sugihara
title Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
title_short Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
title_full Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
title_fullStr Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
title_full_unstemmed Noncoding RNA Expression Aberration Is Associated with Cancer Progression and Is a Potential Biomarker in Esophageal Squamous Cell Carcinoma
title_sort noncoding rna expression aberration is associated with cancer progression and is a potential biomarker in esophageal squamous cell carcinoma
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2015-11-01
description Esophageal cancer is one of the most common cancers worldwide. Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancer in Eastern Asian countries. Several types of noncoding RNAs (ncRNAs) function as key epigenetic regulators of gene expression and are implicated in various physiological processes. Unambiguous evidence indicates that dysregulation of ncRNAs is deeply implicated in carcinogenesis, cancer progression and metastases of various cancers, including ESCC. The current review summarizes recent findings on the ncRNA-mediated mechanisms underlying the characteristic behaviors of ESCC that will help support the development of biomarkers and the design of novel therapeutic strategies.
topic esophageal squamous cell carcinoma
microRNA
long noncoding RNA
cancer initiation
cancer development
biomarker
url http://www.mdpi.com/1422-0067/16/11/26060
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