Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Targeting to the ER

Quantitative Proteomics and Differential Protein Abundance Analysis after Depletion of Putative mRNA Receptors in the ER Membrane of Human Cells Identifies Novel Aspects of mRNA Targeting to the ER

In human cells, one-third of all polypeptides enter the secretory pathway at the endoplasmic reticulum (ER). The specificity and efficiency of this process are guaranteed by targeting of mRNAs and/or polypeptides to the ER membrane. Cytosolic SRP and its receptor in the ER membrane facilitate the co...

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Bibliographic Details
Main Authors: Pratiti Bhadra, Stefan Schorr, Monika Lerner, Duy Nguyen, Johanna Dudek, Friedrich Förster, Volkhard Helms, Sven Lang, Richard Zimmermann
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
endoplasmic reticulum
mRNA targeting
protein targeting
protein import
membrane protein insertion
protein translocation
Online Access:https://www.mdpi.com/1420-3049/26/12/3591

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