High Expression of Glycolytic Genes in Cirrhosis Correlates With the Risk of Developing Liver Cancer

High Expression of Glycolytic Genes in Cirrhosis Correlates With the Risk of Developing Liver Cancer

A marked increase in the rate of glycolysis is a key event in the pathogenesis of hepatocellular carcinoma (HCC), the main type of primary liver cancer. Liver cirrhosis is considered to be a key player in HCC pathogenesis as it precedes HCC in up to 90% of patients. Intriguingly, the biochemical eve...

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Bibliographic Details
Main Authors: Nathan C. W. Lee, Maria Annunziata Carella, Salvatore Papa, Concetta Bubici
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glucose metabolism
aerobic glycolysis
the Warburg effect
liver
liver cancer
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2018.00138/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2018.00138/full

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